The Keratin Proteins and Genes of Wool and Hair

    January 1996 in “ Adelaide Research & Scholarship (AR&S) (University of Adelaide) ”
    Powell Bc
    TLDR Keratin gene regulation was emerging, with a key transcription factor found to influence hair growth and gene expression.
    This review from 1996 outlined the state of knowledge regarding wool keratin proteins and their genes, focusing on structural aspects. It highlighted the significant database of sequence information acquired through molecular techniques over the previous decade, combined with protein data from the '70s and '80s. The review emphasized the challenge of determining the location and interaction of these proteins within the keratin IF/matrix complex. Gene mapping programs were revealing links between keratin genes, impacting the understanding of keratin gene regulation. The study of keratin gene regulation was in its early stages but expected to be an active field. A notable discovery was a transcription factor that regulated both hair keratin gene expression and hair follicle initiation, illustrating the convergence of different research fields.
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