Effect of Keratin-Gelatin and bFGF-Gelatin Composite Film as a Sandwich Layer for Full-Thickness Skin Mesh Graft in Experimental Dogs

    December 2007 in “ Journal of Biomedical Materials Research Part B Applied Biomaterials ”
    S. Thilagar, N. Arul Jothi, A. R. Omar, M. Y. Kamaruddin, S. Ganabadi
    TLDR Keratin-gelatin films improve skin graft success in dogs.
    The study evaluated the effectiveness of keratin-gelatin and bFGF-gelatin composite films as sandwich layers for full-thickness skin mesh grafts in experimental dogs. The research involved three groups of dogs, with group II receiving keratin-gelatin treatment showing promising results. Clinical observations indicated good graft acceptance in this group, evidenced by favorable color, appearance, discharge, and hair growth. Bacteriological examination identified Staphylococcus aureus and Proteus in some animals. Histopathological analysis revealed early presence of hair follicles, sebaceous glands, and normal epidermal thickness in the keratin-gelatin group, suggesting its potential in promoting graft viability compared to the control and bFGF-gelatin groups.
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