Jak Inhibitors in African American Patients With Alopecia Areata: A Case Series

    April 2025 in “ International Journal of Dermatology ”
    Megan M. Mukenge, Saroja Rao, Ivie Obeime, Jorge Larrondo, Victoria Palmer, Amy McMichael
    TLDR JAK inhibitors effectively reduce alopecia areata symptoms in Black patients.
    This study examined the response of Black/African American patients with alopecia areata (AA) to JAK inhibitor (JAKi) therapy, involving 16 patients (14 females, 2 males) with a mean age of 29.6 years. The study found a significant reduction in the Severity of Alopecia Tool (SALT) score by 20.1% after JAKi treatment, indicating effective reduction in scalp involvement. Most patients were treated with baricitinib or ritlecitinib, and 63% showed clinical improvement. The study highlights the importance of JAKi in managing AA among Black patients, with over half of the prescriptions covered by insurance, enhancing access to treatment. Limitations include the small sample size and retrospective design, suggesting the need for further research to explore racial differences in treatment response and to guide early intervention strategies.
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      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
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      community Should I get transplant #4 or just shave my head?

      in Transplants  171 upvotes 1 year ago
      A 36-year-old considering a fourth hair transplant is advised to either shave his head or use a hair system due to poor results from previous transplants and late medication use. He plans to consult top surgeons and adjust his current treatments, including finasteride and minoxidil.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
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      in Research/Science  8 upvotes 3 years ago
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