Jak Inhibitors in the Treatment of Alopecia Areata: A Literature Review

June 2025 in “ Journal of Education Health and Sport ”

Paulina Krzeszowska, Aleksandra Kujawa, Karolina Krochmal, Wojciech Pisarek, Adrianna Samoraj, J Zajaçzkowski, Kacper Stępniak, Jarosław Wilk, Karolina Marrodán-Wojtczak, Radosław Kuźma

Janus kinase inhibitors JAK inhibitors alopecia areata JAK/STAT pathway oral JAK inhibitors topical JAK inhibitors

TLDR Oral JAK inhibitors show promise for treating alopecia areata but have challenges like relapse and side effects.

Janus kinase (JAK) inhibitors are a promising treatment for alopecia areata, targeting the JAK/STAT pathway linked to hair loss. Oral JAK inhibitors show the most potential, but challenges include relapse risk, side effects, and limited effectiveness of topical forms. Ongoing research aims to develop more selective JAK inhibitors and strategies to maintain treatment benefits while addressing high costs.

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community What else is good. Besides the big 3.

in Chat 35 upvotes 8 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 7 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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in Progress Pictures 149 upvotes 2 years ago

User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 8 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community Article of all potential future cures

in Treatment 26 upvotes 1 month ago

Ritlecitinib and PP405 show promise for hair regrowth. Diagnosing the cause of hair loss is crucial before treatment.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.