Platycladus orientalis Leaves: A Systemic Review on Botany, Phytochemistry and Pharmacology

The document reviewed the traditional use and scientific research on Platycladus orientalis leaves, emphasizing their pharmacological properties such as anti-inflammatory, antioxidant, antimicrobial, anticancer, diuretic, hair growth-promoting, neuroprotective, and antifibrotic activities. Active constituents like diterpenes and flavonoids were identified, and the leaves were found to have potential health benefits, including promoting hair growth by inhibiting 5α-reductase. However, the review also pointed out the need for more in vivo studies to validate these findings and to understand the mechanisms behind the leaves' traditional blood-cooling and hematostatic uses. Toxicity was generally low, but high doses could affect liver function and blood indices in rats, and the essential oils could be severely toxic at high concentrations. The document concluded that while the leaves show promise, further research is necessary to elucidate their pharmacological mechanisms and ensure clinical safety.