TLDR Calcium hydroxylapatite can be successfully integrated into healing skin and stimulates collagen.
This observational pilot study investigates the potential of calcium hydroxylapatite (CaHA) to penetrate and integrate into skin treated with a fractional erbium laser. Conducted on a single volunteer, the study utilized reflectance confocal microscopy (RCM) and multiphoton microscopy (MPM) to monitor the effects of the treatment over a 6-week period. The results showed that CaHA microspheres could be successfully incorporated into the dermis and remained present during the healing process. Additionally, the study highlighted new collagen production around the microspheres, as evidenced by the distinct second harmonic generation (SHG) signal observed with MPM. These findings demonstrate the effectiveness of RCM and MPM in noninvasively tracking the integration and impact of CaHA in laser-treated skin.
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