Intradermal Delivery of Calcium Hydroxylapatite With Fractionated Ablation

August 2024 in “ Lasers in Surgery and Medicine ”

William Driscoll, Nicole M. Golbari, Alexander Vallmitjana, Amanda Durkin, Mihaela Balu, Christopher B. Zachary

calcium hydroxylapatite fractional laser treatment reflectance confocal microscopy multiphoton microscopy collagen regeneration collagen stimulator dermis CaHA RCM MPM

Studysummary This study observed that calcium hydroxylapatite can be successfully incorporated and retained in the dermis for at least six weeks after fractional laser treatment, with new collagen forming around it.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This observational pilot study investigates the potential of calcium hydroxylapatite (CaHA) to penetrate and integrate into skin treated with a fractional erbium laser. Conducted on a single volunteer, the study utilized reflectance confocal microscopy (RCM) and multiphoton microscopy (MPM) to monitor the effects of the treatment over a 6-week period. The results showed that CaHA microspheres could be successfully incorporated into the dermis and remained present during the healing process. Additionally, the study highlighted new collagen production around the microspheres, as evidenced by the distinct second harmonic generation (SHG) signal observed with MPM. These findings demonstrate the effectiveness of RCM and MPM in noninvasively tracking the integration and impact of CaHA in laser-treated skin.

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