Interleukin Gene Polymorphism in Alopecia Areata Patients: A Systematic Review

    Abdus Sattar, Nesreen M. Aboraia, Omayma O. Abdelaleem, Amal Talaat Abd El-Rahman
    TLDR Certain gene variations are linked to alopecia areata.
    This systematic review investigates the correlation between interleukin gene polymorphisms and alopecia areata (AA), an autoimmune disorder causing hair loss. The study focuses on specific interleukin genes (IL-12B, IL-15, IL-16, IL-13, IL-12, IL-17A, IL-23, IL-17RA, and IL-18) and their association with AA. The review concludes that polymorphisms in IL-17A, IL-18, IL-17RA, and IL-16 are associated with AA. The authors suggest that further genetic studies are needed to confirm the role of interleukins in the progression of alopecia areata.
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