Concept of Intercultural Communication and Comparative Characteristics of German and Ukrainian Cultures (Based on German Language Material)
January 2010
in “
Nonlinearity in Biology Toxicology Medicine
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → 
Studysummary This review assessed prior rodent studies on low-dose endocrine toxicity and found no confirmatory evidence, suggesting variability in control groups as a major confounding factor.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
The document reviewed attempts to confirm low-dose/hormetic effects in rodent endocrine toxicity studies and concluded that the failure to confirm such effects was largely due to a lack of understanding of confounding influences and the failure to confirm findings before publication. A major confounding factor identified was the variability of parameters within control groups, which becomes more significant when demonstrating weak low-dose effects. This was exemplified in studies with bisphenol A in the mouse uterotrophic assay and finasteride in the Hershberger antiandrogenicity assay, where the ability to demonstrate a low-dose effect depended on the use of concurrent or recent control values.
