Evaluation of Insulin Resistance Markers in Polycystic Ovary Syndrome Patients Receiving Metformin, Finasteride, or Both
December 2025
in “
Annals of the College of Medicine Mosul/Annals of the College of Medecine
”
Studysummary The study found that metformin alone most effectively reduced insulin resistance in Iraqi women with PCOS, but combining metformin with finasteride produced greater improvements in insulin sensitivity markers.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
This study on 150 Iraqi women with PCOS assessed the impact of metformin, finasteride, and their combination on insulin resistance markers over 3 months. All treatments significantly reduced insulin resistance, with metformin alone showing the greatest reduction in HOMA-IR levels. However, the combination of metformin and finasteride resulted in the most significant improvements in the TyG index, TyG-BMI index, and TG/HDL ratio, suggesting enhanced insulin sensitivity. The study concludes that while metformin effectively reduces insulin resistance, its combination with finasteride may provide additional benefits for managing insulin-related issues in PCOS.
