Inhibin A Is Downregulated During Chemotherapy in Patients With Breast Cancer

    March 2010 in “ Ejc Supplements ”
    Julia Jückstöck, Brigitte Rack, Christian Scheffold, Klaus Friese, Ioannis Mylonas
    Image of study
    TLDR Chemotherapy significantly lowers Inhibin A levels in breast cancer patients.
    The study aimed to evaluate the levels of Inhibin A, a glycoprotein involved in human reproduction and endocrine-responsive tumors, in 28 breast cancer patients undergoing chemotherapy. The patients were prospectively monitored before treatment, after completing chemotherapy (3 cycles of FEC and 3 cycles of Docetaxel), and two years post-chemotherapy. Using the Ultrasensitive Inhibin A ELISA, the results showed a significant decrease in Inhibin A levels post-chemotherapy (p<0.005) and at the two-year follow-up (p<0.001), with no significant difference between the post-chemotherapy and two-year follow-up levels (p=0.744). The conclusion drawn was that chemotherapy significantly reduces Inhibin A concentration, potentially indicating suppression of ovarian function and serving as a marker for chemotherapy-induced amenorrhea. Additionally, Inhibin A may act as a tumor marker for breast cancer, where an increase in its levels could signal cancer recurrence.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 262 results

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 month ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Do I get a hair transplant at 22?

      in Transplants  11 upvotes 8 months ago
      A user has been using dutasteride and oral minoxidil for hair loss with no change and is considering a hair transplant at age 22. Replies suggest that a transplant is possible if DHT blockers like finasteride are continued, and another user shared a positive personal experience with a transplant at age 20.

      community There's a guy called Dr. Berg on YouTube who recommended a bunch of supplements for hair health and preventing hair loss. I wrote them all down. Before I buy, can anyone tell me if anything here is BS?

      in Question  7 upvotes 5 years ago
      A user asked about Dr. Berg's recommended supplements for hair health, including Vitamin C, trace minerals, Omega 3, collagen, silica, B-vitamins, stinging nettle root, B6, B2, copper, and Vitamin D. Responses advised against following Dr. Berg, labeling him a quack, and suggested that only stinging nettle root might help with DHT, while the rest are only beneficial if deficient.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 3 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Finastride is a god send miracle FOR ME

      in Finasteride/Dutasteride  203 upvotes 2 years ago
      . This user experienced positive results from using a combination of minoxidil and finasteride, with no reported side effects after two months. Others have also shared their experiences with both short-term and long-term use of finasteride.

    Similar Research

    5 / 1000+ results