Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage

This study explores the use of inflammasome proteins as biomarkers for the inflammatory response in aneurysmal subarachnoid hemorrhage (aSAH), involving 15 aSAH patients and age-matched controls. It found significantly elevated levels of ASC, caspase-1, IL-18, and IL-1β in both serum and cerebrospinal fluid (CSF) of aSAH patients compared to controls. These proteins showed high sensitivity and specificity as biomarkers, with serum levels correlating with worse clinical outcomes. The findings suggest that measuring these protein levels could be useful for monitoring patient outcomes and identifying those at risk for complications, potentially guiding treatment strategies.