Inflammasome Proteins Are Reliable Biomarkers of the Inflammatory Response in Aneurysmal Subarachnoid Hemorrhage

This study investigated the potential of inflammasome signaling proteins as biomarkers for the inflammatory response in aneurysmal subarachnoid hemorrhage (aSAH). The research involved 15 aSAH subjects and control groups, analyzing serum and cerebrospinal fluid (CSF) for inflammasome proteins and cytokines using advanced measurement technologies. Results showed elevated levels of caspase-1, ASC, IL-18, and IL-1β in aSAH patients compared to controls, indicating these proteins as promising biomarkers of inflammation in both CSF and serum. Elevated serum inflammasome proteins were also linked to worse functional outcomes, suggesting their utility in predicting patient prognosis and monitoring clinical outcomes in aSAH.