Changes in Immune Status Parameters in Patients With Alopecia Areata Undergoing Combined Therapy
April 2026
in “
Health care of Tajikistan
”
New to Alopecia Areata? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that patients with alopecia areata receiving combined therapy showed a significant reduction in proinflammatory cytokines and circulating immune complexes, along with increased IL-10 levels and phagocytic activity, suggesting an immunomodulatory effect that reduces inflammation and restores immune balance.
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The study evaluated the immune status changes in 31 patients with alopecia areata undergoing combined therapy, compared to 30 healthy controls. Before treatment, patients showed elevated levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), increased circulating immune complexes, and decreased cellular immunity. Post-treatment, there was a significant reduction in pro-inflammatory cytokines (p <0.01–0.001), a decrease in circulating immune complexes (p <0.05), and an increase in IL-10 levels and phagocytic activity (p <0.05). The combined therapy demonstrated a strong immunomodulatory effect, reducing inflammatory activity and restoring immune homeostasis.
