Imaging Tumor Angiogenesis With Fluorescent Proteins

The document reviewed the use of fluorescent proteins, particularly GFP and RFP, to image tumor angiogenesis through innovative mouse models. These models allowed for real-time, non-invasive visualization of tumor angiogenesis in natural microenvironments, enhancing the understanding of tumor-host interactions and clinical tumor behavior. Techniques such as fluorescence optical imaging and transgenic mice expressing GFP were employed to study blood vessel development in tumors. Notably, nestin-driven GFP transgenic mice revealed that hair follicles contributed to blood vessel formation in the skin. These advancements in imaging techniques provided high-resolution insights into tumor angiogenesis and potential applications in drug screening.