Reduction of Interleukin-6 After PRP-Exosomes Treatment in a Mouse Model of Androgenetic Alopecia

May 2025

Endra Yustin Ellistasari, Suci Widhiati, Indah Julianto, Ervina Rosmarwati, Pristia Widya Monica, Abd Rahaman Yasmin

platelet-rich plasma PRP exosomes androgenetic alopecia minoxidil interleukin-6 IL-6 Rogaine

TLDR PRP-exosomes improve hair growth and reduce inflammation.

This study investigated the effects of platelet-rich plasma (PRP) exosomes on hair growth and inflammation in a mouse model of androgenetic alopecia. Four groups were tested: a control group, a group treated with PRP-exosomes, a group treated with 5% topical minoxidil, and a group treated with both PRP-exosomes and minoxidil. After 32 days, the combination treatment group showed the best hair growth results, followed by the PRP-exosomes and minoxidil groups. The control group exhibited the highest expression of the inflammatory marker IL-6, while the treatment groups showed significantly lower levels, indicating that PRP-exosomes can enhance hair growth and reduce inflammation in this model.

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