A Case of Hypopituitarism Due to Sheehan Syndrome

    October 2024 in “ Journal of the Endocrine Society
    Nwamaka Akabogu, Siroj Dejhansathit, Fnu Marium, Bethany Stanley, Efosa Martins Bazuaye, Lara Sophia Krusniak, Lilamani Kurukulasuriya, Uzma Khan
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    TLDR Sheehan syndrome can cause hormone deficiencies after childbirth, but treatment can improve symptoms.
    Sheehan syndrome, a rare condition in developed countries, results from postpartum pituitary infarction due to severe bleeding, leading to hypopituitarism. This case study involves a 35-year-old woman who experienced severe postpartum hemorrhage 3 years prior, resulting in symptoms like fatigue, weight gain, hair loss, and amenorrhea. Her condition was diagnosed as secondary hypothyroidism, secondary adrenal insufficiency, secondary hypogonadism, low prolactin, and growth hormone deficiency. Treatment with hydrocortisone and thyroid hormone replacement improved her symptoms. The case highlights the importance of thorough history taking and the need to check free T4 levels when pituitary issues are suspected, despite normal TSH levels.
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