Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells

The article discusses the development of humanized animal models using transplantable human iPSC-derived cells to improve disease modeling, drug screening, and understanding of disease mechanisms. Traditional animal models often fail to accurately mimic human physiology and immune responses, limiting their biomedical application. The article highlights recent advancements in gene editing and pluripotent stem cell-based xenotransplantation as promising methods to create more human-like models, particularly focusing on the hematopoietic/immune system and liver. It addresses the challenges of limited engraftment and physiological function in existing models and emphasizes the potential of human pluripotent stem cells as donor sources. The article aims to enhance the development of reliable animal models for clinical and pharmaceutical use by exploring current strategies, advantages, limitations, and emerging trends in the field.