Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells

January 2024 in “ Frontiers in Bioscience-Landmark ”

Min Ma, Jian-Yun Ge, Yunzhong Nie, Yumei Li, Yun‐Wen Zheng

Studysummary This paper reviews current developments in humanized animal models for disease modeling and drug screening, highlighting advances in gene editing and stem cell technologies as key to creating more human-like models for research purposes.

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The article reviews the development of humanized animal models using transplantable human iPSC-derived cells, focusing on overcoming the limitations of traditional animal models in disease modeling and drug screening. It highlights the challenges of limited engraftment rates and physiological functions in existing models and discusses recent advances in gene editing and pluripotent stem cell-based xenotransplantation technologies. The review emphasizes the potential of these technologies to create more human-like models, particularly in the hematopoietic/immune system and liver, and explores their clinical and pharmaceutical applications. The goal is to advance the development of more accurate and reliable animal models for biomedical research.

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