Regeneration of Human Hair Follicles by 3D Bioprinting

July 2021

Lawrence S. Chan

3-D bioprinting hair follicles vascularization collagen gel dermal fibroblasts versican hair morphogenesis hair regeneration hair growth 3D printing skin constructs bioink

TLDR 3-D bioprinting can regenerate human hair follicles using bioink with collagen and fibroblasts.

The chapter discussed the use of 3-D bioprinting for regenerating human hair follicles, highlighting the technical aspects and pros and cons of different bioprinting methods, including laser-based, extrusion-based, and inkjet-based techniques. It explained that 3-D bioprinting aimed to create biologically compatible tissues that mimic natural functions, using bioink composed of collagen gel and human foreskin-derived dermal fibroblasts. The researchers found that without vascularization, 3-D printed skin constructs led to necrosis and failed to support hair growth, prompting them to incorporate vascularization. The study also suggested that versican played a role in hair morphogenesis, regeneration, and normal growth.

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