No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa-Associated Squamous Cell Carcinoma

    August 2010 in “ Journal of Investigative Dermatology ”
    Karin J. Purdie, Céline Pourreyron, Hiva Fassihi, Rodrigo Cepeda‐Valdes, John W. Frew, A. Volz‐Thomas, Sönke Jan Weißenborn, Herbert Pfister, Charlotte M. Proby, Leena Bruckner‐Tuderman, Dédée F. Murrell, Julio C. Salas‐Alanís, John A. McGrath, Irene M. Leigh, Catherine Harwood, Andrew P. South
    TLDR HPV does not cause aggressive cancer in RDEB patients.
    The study investigated the role of human papillomavirus (HPV) in the aggressive nature of squamous cell carcinoma (SCC) associated with recessive dystrophic epidermolysis bullosa (RDEB) by testing 21 SCC samples from 12 RDEB patients for high-risk alpha-papillomavirus (α-PV) and beta-papillomavirus (β-PV). The results showed no significant difference in HPV presence or viral load between RDEB SCC and other cutaneous SCCs, indicating that high copy number HPV infection was not a general feature of RDEB skin. This suggested that HPV was not responsible for the increased incidence and aggressive nature of RDEB-associated SCC.
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