HPLC Determination of Content and Content Uniformity of Finasteride Capsules

    January 2002
    Luo Liu
    TLDR The method accurately measures finasteride in capsules.
    The study established a high-performance liquid chromatography (HPLC) method for determining the content and content uniformity of finasteride capsules. The method used a Waters C18 column with a methanol-water mobile phase and a detection wavelength of 220 nm. Results showed a strong linear relationship within the concentration range of 0.06-0.14 mg/mL, with a correlation coefficient (r) of 0.9996. The method demonstrated an average recovery rate of 99.87% and a relative standard deviation (RSD) of 0.24% across 6 samples, indicating that the method was simple, accurate, and precise.
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