Hormonal Evaluation of Hyperandrogenism in Women

In a study from 2015, a 19-year-old woman presenting with oligomenorrhea, acne, excessive facial hair, and weight gain was evaluated for polycystic ovary syndrome (PCOS). Her hormonal tests revealed elevated levels of total and free testosterone, supporting a PCOS diagnosis, while normal thyrotropin, prolactin, and 17-hydroxyprogesterone levels excluded other endocrine disorders. Despite a normal luteinizing hormone-to-follicle-stimulating hormone ratio, she was diagnosed with PCOS based on her symptoms and hormonal evidence of hyperandrogenism. Treatment included lifestyle changes, hormonal contraceptives, and dietary consultation, leading to weight loss and symptom improvement. The document highlights the importance of both clinical and biochemical hyperandrogenism in diagnosing PCOS, noting the variability and lack of standardization in hormone assays.