Hidradenitis Suppurativa: Symptoms, Diagnostics, and Therapy
April 2019
in “
PubMed
”
hidradenitis suppurativa chronic skin disorder inflammatory nodules fistulas abscesses scarring intertriginous areas terminal hair apocrine glands hyperkeratosis hair follicle occlusion dilatation rupture inflammation smoking obesity topical antiseptics antibiotics systemic TNF-α antagonists surgical intervention skin disorder hair follicle inflammation antiseptics TNF-α blockers surgery
TLDR Hidradenitis suppurativa is a chronic skin condition causing painful lumps and scarring, often triggered by smoking and obesity, and requires varying treatments based on severity.
Hidradenitis suppurativa was a chronic skin disorder marked by recurrent inflammatory nodules, fistulas, abscesses, and scarring, primarily affecting intertriginous areas with terminal hair and apocrine glands. It typically manifested after puberty and persisted for many years, with a prevalence of 0.5% in the Czech Republic. Women were most affected in axillary and inguinal regions, while men were more affected in perianal and gluteal areas. The exact pathogenesis was unknown, but it was believed that hyperkeratosis of the hair follicle led to occlusion, dilatation, and rupture, causing inflammation. Smoking and obesity were major triggers. Without treatment, the disease was chronic and progressive. Treatment varied with severity, ranging from topical antiseptics and antibiotics for mild cases to systemic TNF-α antagonists and surgical intervention for advanced stages, though recurrences were common.
