Hair Plucking and Alopecia in a Flock of Sheep in Zaria, Nigeria

Androgenic alopecia (AGA) might have evolved to reduce prostate cancer risk by increasing UV exposure to the scalp, but this theory is debated. Treatments like minoxidil and finasteride are used for AGA, though the exact causes and evolutionary reasons for hair loss are unclear.

A permanent hair loss solution could involve reprogramming hair follicles to resist DHT using mRNA and siRNA. However, high costs, safety concerns, and the pharmaceutical industry's preference for ongoing treatments over one-time cures are major obstacles, with finasteride and minoxidil remaining standard treatments.

The conversation discusses two methods for making topical finasteride: using ethanol and propylene glycol or mixing it with topical minoxidil. The focus is on solubility and absorption, with a suggestion to crush pills finely and possibly mix with minoxidil at a slightly elevated temperature.

A user has been taking Finasteride for hair loss for 10 months with no results and is considering whether it's due to seasonal shedding or the medication not working. Other users suggest that the dosage might be too low, that some people don't respond to Finasteride, and recommend trying Minoxidil or Dutasteride.

The conversation discusses making homemade topical solutions of dutasteride or finasteride using tablets, with suggestions to use alternatives like MinoxidilMax or stemoxydine due to difficulties in formulation. Some users recommend sticking to oral pills for effectiveness and ease.

The user shared progress pictures showing significant hair regrowth after using finasteride, dutasteride, and minoxidil for over a year. They transitioned from finasteride to dutasteride gradually and noticed hairline regrowth and increased density, with some hair responding better to treatment than others.