The HAIR-AN Syndrome: A Case Report

January 1995

Özcan Balat, Alper Sönmez, Kaya Saraç, Mustafa Şenol

HAIR-AN syndrome insulin resistance acanthosis nigricans hyperandrogenism hirsutism secondary amenorrhea oral contraceptives spironolactone birth control pills Aldactone

TLDR Treatment improved symptoms in a woman with HAIR-AN syndrome.

The HAIR-AN Syndrome, affecting about 5% of hirsute women, was characterized by insulin resistance, elevated insulin levels, acanthosis nigricans, and hyperandrogenism. In this case report, a 21-year-old woman with secondary amenorrhea, hirsutism, and hyperpigmented skin changes was treated with oral contraceptives and spironolactone. After 9 months, she showed significant clinical and hormonal improvement.

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The Hirsute Woman: Challenges in Evaluation and Management

research Effects of a Low-Dose Desogestrel-Ethinylestradiol Combination on Hirsutism, Androgens, and Sex Hormone Binding Globulin in Women with Polycystic Ovary Syndrome

53 citations, January 1985 in “Acta obstetricia et gynecologica Scandinavica”

Low-dose oral contraceptives reduced hair growth and testosterone levels in women with polycystic ovary syndrome.