Green Tea (Camellia Sinensis, L.) Ethanolic Extract as Hair Tonic in Nutraceutical: Physical Stability, Hair Growth Activity on Rats, and Safety Test

January 2014

Juheini Amin, Esther Lamria Purba Simamora, A Effionora, Joshita Djajadisastra

green tea extract ethanolic extract nutraceutical hair tonic hair growth minoxidil physical stability hair length hair diameter hair weight skin safety non-irritating GTE Rogaine

Studysummary This study concluded that a green tea extract hair tonic was stable, promoted more hair growth than 2.5% minoxidil, and did not cause skin irritation.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The study aimed to develop a stable, effective, and safe nutraceutical hair tonic using ethanolic green tea extract (GTE) at concentrations of 2.5%, 5%, and 7.5%. The physical stability of the tonic was tested under various temperatures, and hair growth activity was assessed by measuring hair length, diameter, and weight on rats over 21 days. Safety was evaluated on 9 human volunteers. The results indicated that the hair tonic was stable at room and high temperatures but not at low temperatures. All formulations promoted hair growth more effectively than the synthetic drug minoxidil 2.5%. The tonic was also found to be safe and non-irritating to the skin. The 2.5% GTE concentration was determined to be the most optimal formulation.

View this study on ijppsjournal.com →

Discuss this study in the Community →

Research cited in this study

10 / 10 results

research Hair Growth Promoting Effect of Zizyphus Jujuba Essential Oil

73 citations , March 2010 in “Food and Chemical Toxicology”

This study found that Zizyphus jujuba essential oil enhanced hair growth in mice, with the 1% and 10% concentrations showing increased hair length compared to control.

research Relative Uptake of Minoxidil Into Appendages and Stratum Corneum and Permeation Through Human Skin In Vitro

55 citations , June 2009 in “Journal of Pharmaceutical Sciences”

This study found that ethanol-containing formulations significantly increased minoxidil retention in the stratum corneum and appendages initially, while a propylene glycol-rich formulation enhanced deeper skin penetration over time.

research Diffuse Hair Loss: Its Triggers and Management

88 citations , June 2009 in “Cleveland Clinic Journal of Medicine”

This article reviews various causes of diffuse hair loss, highlighting the importance of identifying triggers through thorough examination for effective treatment and emphasizing patient education in management; it reports no new clinical findings.

research Medical Treatments for Male and Female Pattern Hair Loss

212 citations , September 2008 in “Journal of The American Academy of Dermatology”

This review discusses the various treatment options for male and female pattern hair loss and provides no new clinical results; the authors outline the most effective strategies based on existing evidence.

research Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG)

108 citations , November 2006 in “Phytomedicine”

This study found that EGCG from green tea may stimulate human hair growth by promoting the proliferation and anti-apoptotic activity in dermal papilla cells.

research The Effects of Tea Polyphenolic Compounds on Hair Loss Among Rodents

13 citations , June 2005 in “PubMed”

In this study, 33% of mice treated with polyphenol extract from green tea showed significant hair regrowth, while no control group mice exhibited hair growth.

research A Randomized, Placebo-Controlled Trial of 5% and 2% Topical Minoxidil Solutions in the Treatment of Female Pattern Hair Loss

219 citations , March 2004 in “Journal of The American Academy of Dermatology”

In this 48-week trial, 5% topical minoxidil was more effective than both 2% minoxidil and placebo in promoting hair growth in women with female pattern hair loss, with notable improvements in nonvellus hair count and hair growth assessments.

In Vivo and In Vitro Evaluation of Hair Growth Potential of Hibiscus Rosa-Sinensis Linn.