Graham-Little Piccardi Lassueur Syndrome and Review of the Literature

Graham-Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of Lichen planopilaris (LPP) characterized by a triad of fibrosing alopecia of the scalp, non-fibrosing alopecia of the axilla and groin, and follicular spinous papules over the body. This case report describes a 26-year-old dark-skinned Saudi male with GLPLS, marking the first reported case in Saudi Arabia. The patient exhibited severe pruritus, progressive hair loss, and numerous follicular papules. Treatment with hydroxychloroquine and topical tretinoin showed improvement in pruritus and reduction in follicular papules. The review highlights various treatment options for GLPLS, including PPARγ agonists, hydroxychloroquine, and excimer laser, with varying degrees of success. Early diagnosis and intervention are crucial to prevent progression of hair loss.