Co-Administration of Glyphaea Brevis and Monodora Myristica Modulates Finasteride-Induced Oxidative Stress and Hematological Alterations

August 2025 in “ International Journal of Biochemistry Research & Review ”

Enyohwo Dennis Kpomah, Roland Abeng Okorn

finasteride oxidative stress Glyphaea brevis Monodora myristica antioxidant enzyme lipid peroxidation erythropoiesis phytochemicals Propecia

TLDR Glyphaea brevis and Monodora myristica can protect against finasteride's harmful effects on blood and oxidative stress in male rats.

This study on male Wistar rats explored the effects of Glyphaea brevis (GB) and Monodora myristica (MM) on finasteride-induced reproductive toxicity. Finasteride reduced packed cell volume, red blood cell count, hemoglobin concentration, and platelet count, indicating suppression of erythropoiesis. Co-administration of GB or MM restored these hematological parameters, suggesting protective effects. Finasteride also caused oxidative stress in the testes, reducing antioxidant enzyme activities and increasing lipid peroxidation. GB and MM treatments improved antioxidant enzyme activities and reduced lipid peroxidation, with the combined treatment showing the most significant improvements. These effects are attributed to phytochemicals that enhance antioxidant pathways, indicating GB and MM's potential therapeutic use in male reproductive disorders related to oxidative stress.

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