Co-Administration of Glyphaea Brevis and Monodora Myristica Modulates Finasteride-Induced Oxidative Stress and Hematological Alterations
August 2025
in “
International Journal of Biochemistry Research & Review
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, G. brevis and M. myristica, alone or together, improved hematological and testicular antioxidant parameters in male rats with finasteride-induced reproductive toxicity, showing potential protective effects against oxidative stress and supporting therapeutic use for related male reproductive disorders. Our plain-language summary of this paper — not a Tressless recommendation.
This study on male Wistar rats explored the effects of Glyphaea brevis (GB) and Monodora myristica (MM) on finasteride-induced reproductive toxicity. Finasteride reduced packed cell volume, red blood cell count, hemoglobin concentration, and platelet count, indicating suppression of erythropoiesis. Co-administration of GB or MM restored these hematological parameters, suggesting protective effects. Finasteride also caused oxidative stress in the testes, reducing antioxidant enzyme activities and increasing lipid peroxidation. GB and MM treatments improved antioxidant enzyme activities and reduced lipid peroxidation, with the combined treatment showing the most significant improvements. These effects are attributed to phytochemicals that enhance antioxidant pathways, indicating GB and MM's potential therapeutic use in male reproductive disorders related to oxidative stress.
