Role of Growth Hormone Therapy in Clinical, Laboratory, and Radiological Improvement of Children with Vitamin-D Dependent Rickets Type-2

The study explored the role of growth hormone therapy in children with Vitamin-D Dependent Rickets Type-2 (VDDR-2), a condition characterized by mutations in the vitamin-D receptor leading to symptoms such as alopecia and short stature. The research focused on 3 cases within a family, including 2 sisters and their cousin, who exhibited symptoms like limb deformities and alopecia despite receiving standard treatments. Remarkably, when these children received growth hormone therapy due to growth failure, there was a significant improvement in their rickets symptoms, as evidenced by clinical, laboratory, and radiological assessments. The findings suggested that growth hormone therapy could be beneficial in improving linear growth and alleviating rickets symptoms in VDDR-2 patients, although further studies were needed to confirm these results.