Genes of Congenital Dermatologic Disorders in Dogs: A Review

December 2021 in “ Folia veterinaria ”

Z. Malinovská, E. Čonková

primary seborrhoea ichthyosis hereditary nasal parakeratosis congenital skin diseases genetic tests defective gene variants

TLDR Over half of the dog skin disorders discussed have known gene variants, enabling genetic testing for diagnosis and responsible breeding.

This review article discusses the identified genes responsible for various congenital skin diseases in dogs, which are significant in the breeding of purebred dogs. The diseases covered include primary seborrhoea, ichthyosis, hereditary nasal parakeratosis, and several others, often linked to specific breeds. For over half of these conditions, specific defective gene variants have been identified. Genetic tests for these genes are crucial for diagnosing these diseases and aiding in the breeding process.

View this study on sciendo.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Epidermolysis Bullosa in Animals: A Review

33 citations, October 2014 in “Veterinary Dermatology”

Epidermolysis bullosa is a genetic disease causing fragile skin and blisters in both animals and humans.

Exfoliative Cutaneous Lupus Erythematosus in German Shorthaired Pointer Dogs: Disease Development, Progression, and Evaluation of Three Immunomodulatory Drugs (Ciclosporin, Hydroxychloroquine, and Adalimumab) in a Controlled Environment

research Exfoliative Cutaneous Lupus Erythematosus in German Shorthaired Pointer Dogs: Disease Development, Progression, and Evaluation of Three Immunomodulatory Drugs (Ciclosporin, Hydroxychloroquine, and Adalimumab) in a Controlled Environment

21 citations, April 2010 in “Veterinary Dermatology”

Hydroxychloroquine showed some potential, but overall, the three drugs had limited success in treating lupus in dogs.

research Sebaceous Adenitis in Swedish Dogs: A Retrospective Study of 104 Cases

22 citations, May 2008 in “Acta veterinaria Scandinavica”

English springer spaniels are more prone to severe sebaceous adenitis than standard poodles.

Related Community Posts Join

6 / 282 results

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 11 months ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Primary Care Provider told me to not be concerned and just take biotin.

in Finasteride/Dutasteride 2 upvotes 1 month ago

A 19-year-old was advised by their primary care provider to take biotin for hair loss instead of minoxidil or finasteride due to potential side effects and age concerns. The user is considering seeking a second opinion from a dermatologist.

community If DHT is the one big primary reason for Hairloss.. Then other reasons are hoax?

in Chat 8 upvotes 2 years ago

The conversation discusses various theories and suggestions for hair loss, with a focus on DHT as the primary cause. Treatments mentioned include Minoxidil, finasteride, and RU58841.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 6 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community We need to keep these snake oil companies accountable.

in Treatment 121 upvotes 5 months ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community I love Costco. Fin is less than $3 per month without insurance.

in Finasteride/Dutasteride 128 upvotes 8 months ago

The conversation discusses the affordability of finasteride for hair loss treatment, with users sharing that it can be obtained for less than $3 per month at Costco without insurance, and the cost can be further reduced by getting a year's prescription at once. Some users also mention getting prescriptions from their primary care physician or online services.

Related Research

1 / 1 results

research Follicular Ichthyosis: A Study of Four Patients with Congenital Follicular Hyperkeratosis

17 citations, July 1984 in “British journal of dermatology/British journal of dermatology, Supplement”

The four patients have a unique type of ichthyosis affecting hair follicles.