The Hair Loss Encyclopedia

A Case of Generalized Hair Follicle Hamartoma Associated With Systemic Lupus Erythematosus

July 2004 in “ The Journal of Dermatology ”

Kenta Tsuru, Akiko Ohashi, Masato Ueda

TLDR Generalized hair follicle hamartoma can occur with systemic lupus erythematosus.

The document reported a case of a female patient with systemic lupus erythematosus (SLE) who developed generalized hair-follicle hamartoma (HFH). Generalized HFH was noted to be frequently associated with autoimmune diseases, including SLE. This case was significant as it was the fourth documented instance of generalized HFH occurring in conjunction with SLE.

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Research cited in this study

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research Basaloid follicular hamartoma, total body hair loss and SLE

37 citations , March 1998 in “Lupus”

Aggressive SLE treatment helped hair regrowth and improved oral plaque, but scalp lesions stayed.

research Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

638 citations , October 1997 in “Nature”

research Generalized trichoepitheliomas with alopecia and myasthenia gravis: Clinicopathologic and immunohistochemical study and comparison with classic and desmoplastic trichoepithelioma

54 citations , November 1986 in “Journal of the American Academy of Dermatology”

Generalized trichoepitheliomas with hair loss may indicate myasthenia gravis.

research Generalized Hair Follicle Hamartoma Associated With Alopecia And Myasthenia Gravis: Report Of A Second Case

64 citations , May 1981 in “Clinical and Experimental Dermatology”

A possible link exists between hair follicle abnormalities, hair loss, and muscle weakness.

research Generalized Hair-Follicle Hamartoma

61 citations , April 1969 in “Archives of Dermatology”

Skin biopsy is crucial for diagnosing unknown baldness causes.