From molecular biology to therapeutics

The document "From molecular biology to therapeutics" from 1994 provided insights into various pathological processes and therapeutic approaches. It covered structural protein expression in skin disorders like ichthyoses and epidermolysis bullosa, mechanisms of retinoic acid in photoaging, and cell trafficking in inflammatory dermatoses. It also discussed the regulation of keratin gene expression by hormones and vitamins, the role of the steroid/retinoid hormone receptor super-family, and synthetic retinoids. Additionally, it reviewed cytokine modulation of collagen and elastin gene expression, growth factors in melanocytes and melanoma, and the release of interleukins in psoriatic epidermal cells. New therapeutic approaches included the use of all-trans-retinoic acid in leukemia, vitamin D3 analogues in psoriasis, and viral vectors for gene transfer.