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Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions

research Modulation of Photoaging-Induced Cutaneous Elastin: Evaluation of Gene and Protein Expression of Markers Related to Elastogenesis Under Different Photoexposure Conditions

14 citations , October 2021 in “Dermatology and Therapy”

This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.

Minoxidil Improves Vascular Compliance, Restores Cerebral Blood Flow, and Alters Extracellular Matrix Gene Expression in a Model of Chronic Vascular Stiffness

research Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness

34 citations , July 2018 in “American Journal of Physiology-heart and Circulatory Physiology”

Minoxidil improves blood flow and vessel flexibility, potentially helping with vascular stiffness.

research From molecular biology to therapeutics

7 citations , June 1994 in “International journal of biochemistry/International Journal of Biochemistry”

This review explores various topics related to skin diseases, hormones, receptors, growth factors, and therapeutic approaches, but it provides no new research findings.

research Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study

15 citations , December 2013 in “Clinical Cosmetic and Investigational Dermatology”

This study found that levels of the protein MAGP-1, important for skin elasticity, decrease with aging and photoexposure, potentially contributing to skin fragility, sagging, and enlarged pores.

research Inhibitory effect of tianeptine on catagen induction in alopecia areata-like lesions induced by ultrasonic wave stress in mice

7 citations , April 2013 in “Clinical and Experimental Dermatology”

This study found that tianeptine may suppress the transition to catagen, promoting hair growth in a stress-induced alopecia areata mouse model.

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community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 245 upvotes 1 year ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community Long term finasteride users; Did you notice any improvement after 2 years?

in Finasteride/Dutasteride 14 upvotes 3 years ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community A less common type of hairloss case

5 upvotes 5 months ago

High-dose Lysine and Histidine supplements caused curly/kinky hair and shedding due to Elastin dysfunction. Minoxidil, white tea, and dark grape juice were mentioned as treatments to inhibit Elastase and mimic Lysyl Oxidase.

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