Formulation of Anti-Hair Loss Agents in New Cosmetic Carriers and Assessment of Their Action
October 2018
TLDR Liposomes with minoxidil and PEP penetrate skin slowly but reach deeper layers than foam.
The study investigated the formulation of anti-hair loss agents into liposomes and assessed their effectiveness. Liposomes containing minoxidil and myristoyl dipeptide-13 (PEP) were prepared and tested for stability under various conditions. Results showed that liposomes with both agents likely oxidized at 25°C and 45°C, with PEP liposomes also showing increased viscosity at 4°C and 25°C. Minoxidil's encapsulation rate remained stable, while PEP's decreased over time, especially at 4°C. Permeability tests on healthy volunteers indicated that both agents, when encapsulated in liposomes, penetrated the skin's stratum corneum more slowly but reached deeper layers compared to conventional foam formulations.