Formulation of Anti-Hair Loss Agents in New Cosmetic Carriers and Assessment of Their Action
October 2018
New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study observed that liposomes encapsulating minoxidil and PEP penetrate the skin at a slower rate but may reach deeper layers compared to a foam formulation. Our plain-language summary of this paper — not a Tressless recommendation.
The study investigated the formulation of anti-hair loss agents into liposomes and assessed their effectiveness. Liposomes containing minoxidil and myristoyl dipeptide-13 (PEP) were prepared and tested for stability under various conditions. Results showed that liposomes with both agents likely oxidized at 25°C and 45°C, with PEP liposomes also showing increased viscosity at 4°C and 25°C. Minoxidil's encapsulation rate remained stable, while PEP's decreased over time, especially at 4°C. Permeability tests on healthy volunteers indicated that both agents, when encapsulated in liposomes, penetrated the skin's stratum corneum more slowly but reached deeper layers compared to conventional foam formulations.
