Folliculosebaceous Cystic Hamartoma With Spindle Cell Lipomatous And Neural Components
June 2023
in “
Dermatopathology
”
folliculosebaceous cystic hamartoma FSCH follicular structure sebaceous glands mature adipose tissue fibromyxoid stroma CD34-positive spindle cells S100-positive neural structures SMA-positive vascular structures hair follicle sebaceous gland fat tissue connective tissue spindle cells nerve cells vascular structures
TLDR A woman had a unique skin growth with hair follicle, oil glands, fat cells, spindle cells, and nerve fibers.
This report describes a rare case of folliculosebaceous cystic hamartoma (FSCH) in a 55-year-old woman, presenting as a 10 × 9 mm nodule on her nose. The lesion, excised without complications, exhibited a mix of follicular, sebaceous, and mesenchymal tissues, including spindle cell lipomatous and neural components. Histopathological examination revealed a dilated follicular structure with hypertrophic sebaceous glands, mature adipose tissue, and fibromyxoid stroma containing CD34-positive spindle cells, S100-positive neural structures, and SMA-positive vascular structures. The lesion was benign, with no cytologic atypia or mitotic figures. This case underscores the diagnostic complexity of FSCH, particularly with the presence of rare spindle cell lipomatous and neural components.
