The First Case of Extensive Metastatic Pancreatic Mixed Acinar-Neuroendocrine Carcinoma in a Cat

    January 2025 in “ Pakistan Veterinary Journal ”
    TLDR A cat had a rare, aggressive pancreatic cancer that spread quickly and led to its death.
    This report details the first known case of extensive metastatic pancreatic mixed acinar-neuroendocrine carcinoma (MANEC) in a 10-year-old male castrated cat, which presented with alopecia, anorexia, and weight loss. Diagnostic imaging revealed significant pancreatic abnormalities and metastases. Despite supportive care, the cat's condition worsened, leading to its death within 10 days. Postmortem examination confirmed the presence of neoplastic cells with both exocrine and neuroendocrine characteristics, and metastases were found in multiple organs. This case emphasizes the diagnostic challenges of feline pancreatic MANEC and the importance of considering it in differential diagnoses of pancreatic masses with mixed histologic features.
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