TLDR Finasteride is not effective for older women with hair loss.
The document discussed the effectiveness of finasteride, a 5α-reductase inhibitor, in reducing dihydrotestosterone (DHT) levels in the serum and scalp, which was effective in men with androgenetic alopecia (AGA). However, its effectiveness in women, particularly older women with AGA, had not been thoroughly investigated. The pathophysiology of AGA was similar in both men and women, but the milder and less patterned expression in women might have been due to differences in 5α-reductase and aromatase levels, as well as androgen receptors in scalp hair follicles compared to men.
239 citations
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November 2000 in “Journal of The American Academy of Dermatology” Finasteride doesn't effectively treat hair loss in postmenopausal women.
32 citations
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April 1999 in “Expert Opinion on Investigational Drugs” Finasteride effectively treats male hair loss, improving growth and density.
20 citations
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April 2006 in “Dermatologic Clinics” Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.
1 citations
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July 2017 in “The Journal of Urology” Low-dose finasteride and dutasteride reduce PSA levels by 27.8% in men with male androgenetic alopecia.
3 citations
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January 2001 in “Cambridge University Press eBooks” Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
50 citations
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February 2013 in “Annals of Clinical Biochemistry” Understanding how DHT works is important for diagnosing and treating hormone-related disorders.
47 citations
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April 2003 in “Journal of dermatological science” Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.
