Determination of Finasteride in Human Plasma and Its Pharmacokinetics and Relative Bioavailability by HPLC-Electrospray Mass Spectrometry

    January 2006
    Jianhua Li
    TLDR Two finasteride tablet formulations are bioequivalent.
    The study developed a new HPLC-MS method to determine finasteride levels in human plasma and assessed the pharmacokinetics and relative bioavailability of two finasteride tablet formulations in 20 healthy male volunteers. The method showed a linear calibration curve for finasteride concentration and high recovery rates. Pharmacokinetic parameters such as C_max, AUC_(0-24), t_(1/2), and t_(max) showed no significant differences between the two formulations. The relative bioavailability of one tablet formulation compared to the other was 99.3%, indicating bioequivalence between the two.
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