Determination of Finasteride by HPLC-MS and Study Its Pharmacokinetics

    January 2006 in “ The Chinese Journal of Modern Applied Pharmacy ”
    Gu Ping
    TLDR A new method accurately measures finasteride levels in blood and shows how the body processes it.
    The study developed a sensitive and specific HPLC-MS method to determine finasteride levels in plasma and examined its pharmacokinetics in 18 healthy volunteers after administering a 5 mg oral dose. The method involved protein precipitation with acetonitrile and used a Nucleodur C18 column with a mobile phase of acetonitrile and ammonium acetate. The results showed a linear range of 1.53-306.70 ng/mL with high recovery rates and low variability. Key pharmacokinetic parameters included a t_max of 1.59 hours, C_max of 47.16 ng/mL, and AUC_0-24 of 319.29 ng·h/mL. The plasma concentration-time curve followed a two-compartment open model, with significant individual variability in pharmacokinetics.
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