Eyes open on stem cells

    November 2023 in “ Stem Cell Reports ”
    Anna Altshuler, Aya Amitai-Lange, Waseem Nasser, Shalini Dimri, Swarnabh Bhattacharya, Beatrice Tiosano, Ramez Barbara, Daniel Aberdam, Shigeto Shimmura, Ruby Shalom‐Feuerstein
    TLDR Stem cells in the cornea show unexpected flexibility and have important implications for medicine.
    The murine cornea has become a significant model for studying stem cells (SCs), enabling the tracing of individual SCs in living animals. Historically, the cornea has been central to major advancements in SC biology and regenerative medicine, including the first corneal transplantation in 1905 and the identification and transplantation of limbal SCs to restore vision in the 1990s. Recent studies have uncovered unexpected properties of SCs and progenitors, highlighting the flexibility of their differentiation program and the crucial role of the SC niche. The limbal SC model is discussed for its broader implications for other tissues, diseases, and therapeutic applications.
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