Expression of type I hair keratins in follicular tumours

May 2001 in “ British Journal of Dermatology ”

B. Cribier, Bernard Peltre, Lutz Langbein, Hermelita Winter, J. Schweizer, E Grosshans

TLDR Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

The study on pilomatrixomas, a type of follicular tumor, revealed that as these tumors mature into large areas of shadow cells, there was a gradual loss of differentiation-specific hair keratins. This change in hair keratin expression patterns supported the hypothesis that pilomatrixomas originated from the hair matrix, as evidenced by the complex hair keratin expression observed in these tumors.

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research Expression of type I hair keratins in follicular tumours

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Pilomatrixomas likely originate from the hair matrix due to changes in hair keratin expression.

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins.

238 citations , May 1989 in “Journal of Investigative Dermatology”

Expression of type I hair keratins in follicular tumours

Research cited in this study

research Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

research Characterization of a 300 kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain

research Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation

research Identification of Novel Mutations in Basic Hair Keratins hHb1 and hHb6 in Monilethrix: Implications for Protein Structure and Clinical Phenotype

research The Catalog of Human Hair Keratins

research WNT Signaling in the Control of Hair Growth and Structure

research Spiny keratoderma ‐ a demonstration of hair keratin and hair type keratinization

research A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle

research Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes

research Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix

research Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes

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research Expression of type I hair keratins in follicular tumours

research Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest it Evolved from Keratinocyte Keratins.