Determination of Exemestane in Human Plasma by LC-MS/MS

    January 2007 in “ Zhōnghuá yàoxué zázhì ”
    Bin Di
    TLDR The method effectively showed that the two exemestane preparations are bioequivalent.
    The study developed a high-performance liquid chromatographic mass spectrometric method to determine exemestane levels in human plasma and assess the bioequivalence of two preparations. Using a lichrospher C18 chromatographic column and a Finnigan TSQ tandem mass spectrometer, the method demonstrated a linear standard curve for exemestane detection. The pharmacokinetic parameters for the test and reference preparations were similar, with half-lives of approximately 13.37 hours and 15.65 hours, respectively, and maximum concentrations around 20 μg·L-1. The study concluded that the method was simple, sensitive, and suitable for clinical pharmacokinetics or bioequivalence studies, confirming that the two preparations were bioequivalent.
    Discuss this study in the Community →

    Related Community Posts Join

    4 / 4 results

      community 1 year later, min 2ml daily, fin 1mg to 0.5 daily + microneedling

      in Finasteride/Dutasteride  147 upvotes 2 years ago
      The user, Salt_Ad6339, shares their positive experience with hair regrowth after using minoxidil and finasteride for a year, along with microneedling. However, they also mention experiencing chest/nipple pain and suspect it may be a side effect of finasteride. They decide to stop using it for now and see if minoxidil alone can maintain their hair. Other users in the conversation discuss the potential side effects of finasteride and suggest using an aromatase inhibitor to counteract them.

      community Finasteride doubled my testosterone & estrogen

      in Chat  265 upvotes 3 weeks ago
      Finasteride increased testosterone and estrogen, stopped hair loss, and promoted regrowth. Users discussed side effects like libido changes and considered adding minoxidil and aromatase inhibitors.

      community 6 months aggressive treatment for hair loss

      in Progress Pictures  115 upvotes 1 year ago
      The user shared a 6-month aggressive hair loss treatment progress, using oral minoxidil, finasteride/minoxidil topical, dutasteride, derma stamping, Nizoral, and daily Cialis, which notably improved regrowth. Commenters observed significant improvement, with one noting a change from a Norwood 5 to a Norwood 1 in hair loss classification.

    Similar Research

    5 / 76 results