Evaluación de la seguridad de minoxidil oral a dosis bajas en el tratamiento de la alopecia

This thesis evaluates the safety of low-dose oral minoxidil (LDOM) for treating various types of alopecia. Through a meta-analysis and a large retrospective multicentric study involving 1404 patients, it was found that LDOM has a favorable safety profile, with adverse effects (AEs) occurring in 20.6% of patients. The most common AE is hypertrichosis (15.1%), while systemic AEs occur in 5.5% of patients. Most AEs are mild and resolve with dose reduction, with only 1.7% of patients needing to discontinue treatment. In hypertensive patients, systemic AEs occur in 6.8%, with treatment suspension in 1.5%. The study confirms LDOM's good safety profile and provides recommendations for managing AEs.