Factors in the Etiopathogenesis of Post-Adolescent Female Acne

The study included 45 female patients with post-adolescent acne and 30 healthy controls, focusing on the etiopathogenesis of acne that persists or starts after age 25. It found that patients with post-adolescent acne had a higher prevalence of menstrual abnormalities, hirsutism, androgenetic alopecia, metabolic syndrome (MS), and polycystic ovary syndrome (PCOS). Higher levels of total testosterone (TT) and luteinizing hormone (LH) were observed in patients compared to controls, but no significant differences were found in other hormonal assessments or in fasting blood glucose, fasting insulin, and lipid levels. The study concluded that insulin resistance and dyslipidemia might not play a major role in the pathogenesis of post-adolescent female acne, despite the presence of clinical features suggestive of hyperandrogenism.