Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice
August 2010
in “Journal of Dermatological Science”
TLDR Erythropoietin helps hair grow and could be a potential treatment for hair loss.
In the 2010 study, erythropoietin (EPO) was shown to stimulate hair growth by promoting the proliferation of dermal papilla cells (DPCs) and elongating hair shafts in cultured human hair follicles, as well as inducing and prolonging the anagen phase in mice. EPO treatment led to increased cell viability and proliferation, particularly noted by a rise in Ki-67-positive matrix keratinocytes, which are markers of cell proliferation. The expression of EPO and its receptor (EPOR) was found to be highest during the anagen phase of the hair cycle. These findings suggest that EPO and its analogs could be potential treatments for hair loss conditions, as they can modulate hair growth through the stimulation of DPCs that express functional EPOR. The research was funded by the Korea Research Foundation Grant and the Korean Ministry of Education, Science and Technology.
View this study on jdsjournal.com →
Cited in this study
research l-Ascorbic acid 2-phosphate promotes elongation of hair shafts via the secretion of insulin-like growth factor-1 from dermal papilla cells through phosphatidylinositol 3-kinase
Vitamin C derivative helps hair grow longer by making cells produce a growth factor through a specific cellular pathway.
research Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes
A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.
research Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin
research Molecular Control of Epithelial–Mesenchymal Interactions During Hair Follicle Cycling
Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
research Simple and rapid method to isolate and culture follicular papillae from human scalp hair follicles
Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.
research Noggin is required for induction of the hair follicle growth phase in postnatal skin
Noggin is necessary to start the hair growth phase in skin after birth.
research The secret life of the hair follicle
Hair follicles create different cell layers and proteins, controlled by various molecules.
Related
research Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice
Erythropoietin helps hair grow and could be a potential treatment for hair loss.