Loose Anchoring of Anagen Hairs and Pili Torti Due to Erlotinib

    January 2016 in “ International Journal of Trichology ”
    Rodrigo Pirmez, Juan Piñeiro‐Maceira, CarmenGloria Gonzalez, Mariya Miteva
    Studysummary This case report describes two patients who experienced loose anagen hairs and pili torti, resulting in nonscarring alopecia, potentially linked to erlotinib treatment for solid tumors.
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    Research cited in this study 4

    1. Arrow Sign: A Rapid Microscopic Diagnosis of Hair Change Associated with Epidermal Growth Factor Receptor Inhibitors Journal of the American Academy of Dermatology · 2013
    2. LPA-Producing Enzyme PA-PLA1α Regulates Hair Follicle Development by Modulating EGFR Signaling The EMBO Journal · 2011
    3. Abnormal Inner Root Sheath of the Hair Follicle in the Loose Anagen Hair Syndrome: An Ultrastructural Study Journal of the American Academy of Dermatology · 2010
    4. Expression of a Dominant Negative Mutant of Epidermal Growth Factor Receptor in the Epidermis of Transgenic Mice Elicits Striking Alterations in Hair Follicle Development and Skin Structure. The EMBO Journal · 1995