Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation

August 2007 in “ PLoS ONE ”

Michaela Frye, Amanda G. Fisher, Fiona M. Watt

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Research cited in this study

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research Heterogeneous Stem Cells in Skin Homeostasis and Wound Repair

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research Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis

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research Manipulation of stem cell proliferation and lineage commitment:visualisation of label-retaining cells in wholemounts of mouse epidermis

421 citations , September 2003 in “Development”

Stem cell behavior varies with stimuli, and lineage changes can happen without affecting stem cell division.

research Evidence That Myc Activation Depletes the Epidermal Stem Cell Compartment by Modulating Adhesive Interactions with the Local Microenvironment

182 citations , May 2003 in “Development”

Myc activation reduces skin stem cells by affecting cell adhesion.

research Deregulated expression of c-Myc depletes epidermal stem cells

315 citations , June 2001 in “Nature Genetics”

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.