Hair Growth-Related Enzyme Activity and Cytokine Expression Changes Induced by Sandalwood Oil Application in C57BL/6 Mice

    January 2015 in “ 대한미용학회지 ”
    이복순, 홍성희, 김영철
    TLDR Sandalwood oil promotes hair growth in mice.
    The study investigated the effects of sandalwood oil (SO) on hair growth in C57BL/6 mice by examining enzyme activity and cytokine expression. Mice were divided into three groups: normal (saline), positive control (3% minoxidil), and experimental (3% SO). SO was applied topically for four weeks, and changes were observed over 16 weeks. Both the positive control and experimental groups showed significantly higher alkaline phosphatase (ALP) activity and increased mRNA expression of hair growth-promoting factors (prolactin and VEGF) compared to the normal group. Additionally, the mRNA expression of the hair growth inhibitory factor TGF-β1 was significantly decreased in these groups. The findings suggested that ALP activity and the mRNA levels of PRL, VEGF, and TGF-β1 could serve as markers for the hair growth cycle.
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