Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites

July 2013 in “ Amino Acids ”

Candace S. Hayes, Karen DeFeo-Mattox, Patrick M. Woster, Susan K. Gilmour

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Research cited in this study

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research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations, February 2002 in “Carcinogenesis”

research A Definitive Role of Ornithine Decarboxylase in Photocarcinogenesis

67 citations, September 2001 in “American Journal Of Pathology”

Inhibiting ODC can prevent UV-induced skin cancer.

research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

1010 citations, August 2000 in “Cell”

Hair follicle stem cells can form both hair follicles and skin.

research K6/ODC transgenic mice as a sensitive model for carcinogen identification

57 citations, July 2000 in “Toxicology Letters”

research Co-operation between follicular ornithine decarboxylase and v-Ha-ras induces spontaneous papillomas and malignant conversion in transgenic skin

88 citations, August 1998 in “Carcinogenesis”

research Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.

233 citations, July 1997 in “PubMed”