Immunolocalization of Epidermal Growth Factor (EGF) in Burn Wounds of White Rats (Rattus Norvegicus) Induced by Mesenchymal Stem Cell Growth Medium Extract

January 2016

Muh. Husni Thamrin, M.P. drh. Teguh Budipitojo, M.P. drh. Yuda Heru Fibrianto

epidermal growth factor EGF mesenchymal stem cell-conditioned medium MSC-CM hair follicles collagen fiber epidermal re-epithelialization Bioplacenton

TLDR MSC-CM cream speeds up burn wound healing better than the control treatment.

This study investigated the role of epidermal growth factor (EGF) in the regeneration of burn wounds in 48 Wistar rats treated with mesenchymal stem cell-conditioned medium (MSC-CM) cream. The presence and distribution of EGF were analyzed over 30 days. EGF was detected with dense intensity in hair follicles by day 2 and in the epidermis by day 5 in the MSC-CM group, with increased intensity by day 10. The MSC-CM group showed faster wound closure, higher collagen fiber density, and quicker epidermal re-epithelialization compared to the control group treated with Bioplacenton®. This suggests that MSC-CM cream enhanced the burn wound healing process more effectively than the control treatment.

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