Immunolocalization of Epidermal Growth Factor (EGF) in Burn Wounds of White Rats (Rattus Norvegicus) Induced by Mesenchymal Stem Cell Growth Medium Extract

January 2016

Muh. Husni Thamrin, M.P. drh. Teguh Budipitojo, M.P. drh. Yuda Heru Fibrianto

epidermal growth factor EGF mesenchymal stem cell-conditioned medium MSC-CM hair follicles collagen fiber epidermal re-epithelialization Bioplacenton

TLDR MSC-CM cream speeds up burn wound healing better than the control treatment.

The study investigated the role of epidermal growth factor (EGF) in the regeneration of burn wounds in rats treated with mesenchymal stem cell-conditioned medium (MSC-CM) cream. Forty-eight 2-month-old Wistar rats were divided into two groups: one treated with Bioplacenton® and the other with MSC-CM cream. EGF immunoreactivity was detected with dense intensity in the hair follicles by day 2 and in the epidermis by day 5 in the MSC-CM group, with increased intensity by day 10. The MSC-CM group showed accelerated wound closure, higher collagen fiber density, and faster re-epithelialization compared to the control group, indicating that MSC-CM cream enhanced the skin regeneration process.

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