The Expression Characteristics and Their Biological Significance of Epidermal Growth Factor and Basic Fibroblast Growth Factor in Rat Skins at Different Development Stages

    January 2001 in “ Chinese Journal of Reparative and Reconstructive Surgery ”
    Yinhui Yang
    TLDR EGF aids skin development and healing, while bFGF absence in embryos may allow scar-free healing.
    The study investigated the expression of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) in rat skin across different developmental stages. EGF was present in the skin of embryonic, newborn, and adult rats, with increasing expression as the rats aged, suggesting its role in epidermal development and wound healing. In contrast, bFGF was absent in embryonic skin but present in newborn and adult rats, indicating that the lack of bFGF might contribute to non-scar healing during the embryonic stage.
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