Efficacy of Tofacitinib as an Induction Agent in Severe Alopecia Areata Compared to Oral Betamethasone Weekly Pulse

April 2024 in “ Clinical and experimental dermatology ”

Rhea Ahuja, Vishal Patel, Ayush Jain, Neha Taneja, Somesh Gupta

tofacitinib alopecia areata oral betamethasone oral mini-pulse therapy scalp hair loss pulse steroids Xeljanz AA OMP

TLDR Tofacitinib is effective for severe alopecia areata, similar to oral betamethasone.

The study evaluates the efficacy of tofacitinib as an induction agent for severe alopecia areata (AA), characterized by ≥ 50% scalp hair loss, in comparison to the standard oral mini-pulse (OMP) therapy. The findings suggest that tofacitinib is a promising induction agent for patients with severe AA, showing comparable results to OMP. However, for patients who do not respond adequately to tofacitinib, a trial of pulse steroids may be considered as an alternative treatment option.

View this study on academic.oup.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 7 results

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 26 upvotes 4 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 864 upvotes 4 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community What else is good. Besides the big 3.

in Chat 34 upvotes 4 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community The shedding caused by Minoxidil is one of the worst things. 2 months apart each picture

in Progress Pictures 290 upvotes 6 months ago

The conversation discusses the severe shedding caused by Minoxidil, with users sharing their experiences and outcomes. Some report eventual regrowth, while others see no improvement or worsening hair loss.

community 22F. Should I even bother getting a biopsy? Is there any point?

7 upvotes 8 years ago

A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

community No hair, don't care! [24/F] :)

61 upvotes 8 years ago

A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

Related Research

3 / 3 results

research Resistant Alopecia Areata Treated with Tofacitinib

1 citations, September 2022 in “International Journal of Trichology”

Tofacitinib can be effective in treating hair loss caused by alopecia areata.

research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.

research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

4 citations, July 2018 in “PubMed”

Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.