Efficacy of Tofacitinib as an Induction Agent in Severe Alopecia Areata Compared to Oral Betamethasone Weekly Pulse

April 2024 in “ Clinical and experimental dermatology ”

Rhea Ahuja, Vishal Patel, Ayush Jain, Neha Taneja, Somesh Gupta

tofacitinib alopecia areata oral betamethasone oral mini-pulse therapy scalp hair loss pulse steroids Xeljanz AA OMP

TLDR Tofacitinib is effective for severe alopecia areata, similar to oral betamethasone.

The study evaluates the efficacy of tofacitinib as an induction agent for severe alopecia areata (AA), characterized by ≥ 50% scalp hair loss, in comparison to the standard oral mini-pulse (OMP) therapy. The findings suggest that tofacitinib is a promising induction agent for patients with severe AA, showing comparable results to OMP. However, for patients who do not respond adequately to tofacitinib, a trial of pulse steroids may be considered as an alternative treatment option.

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